Formic Acid
Formic acid (HCOOH) is naturally-occurring, flammable, corrosive, organic, and the simplest carboxylic acid. Used as a hydride ion source in synthetic organic chemistry, a mobile phase component in HPLC, a preservative/antibacterial agent in agriculture, etc.
Formic or methanoic acid (CAS: 64-18-6; PubChem ID: 284) is a colorless organic acid with the formula HCOOH. At ambient temperatures, it has a strong, penetrating odor, like acetic acid. Used in chemical synthesis as an intermediate, this simple carboxylic acid is miscible in water and most organic solvents and is somewhat hydrocarbon-soluble.
Formic acid occurs naturally in the venom of some ants and bees. Formate, the conjugate base of formic acid, also occurs naturally in bodily fluids following methanol poisoning.
Formic acid is a source of hydride ion in synthetic organic chemistry, as in the Eschweiler-Clarke and Leuckart-Wallach reactions. It is also a useful component of the mobile phase in reversed-phase high-performance liquid chromatography (RP-HPLC) for peptides, proteins, and intact viruses.
Although formic acid is easily metabolized and eliminated, it can have toxic effects. Methanol metabolism produces formic acid and formaldehyde, which are responsible for the optic nerve damage that results from methanol poisoning. Chronic exposure in humans may cause kidney damage and skin allergies in some people.
In diluted forms, formic acid and formate esters are used as artificial flavorings and perfume additives. In higher concentrations, formic acid is flammable, and skin and eye contact with concentrated liquid or vapors is dangerous.
In agriculture, formic acid is used as a preservative and antibacterial agent and by beekeepers to kill mites. It is useful in leather tanning, textile dyeing and finishing, and in rubber production. Formic acid replaces mineral acids in limescale removers and other cleaning products.
![eMolecules 64-18-6 | Formic Acid[for LC-MS] | TCI America | MFCD00003297 | 46.025 | CH2O2 | 98 | OC=O | 25ml | 115078985](https://assets.fishersci.com/TFS-Assets/CCG/product-images/NC2396979.JPG-250.jpg)
eMolecules 64-18-6 | Formic Acid[for LC-MS] | TCI America | MFCD00003297 | 46.025 | CH2O2 | 98 | OC=O | 25ml | 115078985
Formic Acid[for LC-MS] | TCI America | 64-18-6 | MFCD00003297 | 46.025 | CH2O2 | 98.000 | OC=O | 25ml | 115078985
Medchemexpress LLC MRTX-EX185 formic | 2988148-70-3 | 97.23% | C34H35FN6O4 | 1 ML
MRTX-EX185 formic is a potent KRAS (G12D) inhibitor with an IC50 of 90 nM. It binds to both GDP-loaded and active GNP states of KRAS and KRAS (G12D). This compound exhibits broad-spectrum binding properties and can be utilized for studying various RAS-driven tumors, such as pancreatic cancer.
- Suppresses cell proliferation in KRAS (G12D)-driven SW-1990 pancreatic cancer cells with an IC50 of 70 nM.
- Non-toxic to non-KRAS-dependent cell lines (HEK293 cells).
- Significantly inhibits ERK phosphorylation (p-ERK) in KRAS(G12C)-driven cell lineages.
LAB ALLEY Formic Acid 99% LC/MS Grade
Formic Acid is the simplest carboxylic acid containing only one carbon. It is a colorless liquid with a pungent aroma. It is about 10 times stronger than Acetic Acid. The high acidity level and reducing nature of this compound makes it different from other carboxylic acids. LC/MS is a versatile technique that combines the physical separation property of Liquid Chromatography with the mass analysis property of Mass Spectroscopy. LC-MS Grade Formic Acid is high-purity solvent for preparing elution solvents for HPLC separations of protein and peptides. LC/MS Grade Formic Acid is well suited as a chromatography additive for use in LCMS and HPLC applications.
Sigma Aldrich Fine Chemicals Biosciences Formic acid reagent grade, >=95% | 64-18-6 | MFCD00003297 | 100ML
Formic acid reagent grade, >=95% | Purity: >=95% | Mol Wt: 46.03 | 64-18-6 | MFCD00003297 | 100ML
Sigma Aldrich Fine Chemicals Biosciences Formic acid >=95%, FCC, FG | 64-18-6 | MFCD00003297 |
Formic acid >=95%, FCC, FG | Purity: >=95% | Mol Wt: 46.03 | 64-18-6 | MFCD00003297 |
Sigma Aldrich Fine Chemicals Biosciences Formic acid ACS reagent, >=88% | 64-18-6 | MFCD00003297 | 100ML
Formic acid ACS reagent, >=88% | Purity: >=88% | Mol Wt: 46.03 | 64-18-6 | MFCD00003297 | 100ML
Formic Acid (Aldehyde-Free/Sequencing), Fisher BioReagents™
CAS: 64-18-6 Molecular Formula: CH2O2 Molecular Weight (g/mol): 46.025 InChI Key: BDAGIHXWWSANSR-UHFFFAOYSA-N Synonym: methanoic acid,formylic acid,aminic acid,bilorin,hydrogen carboxylic acid,formisoton,myrmicyl,formira,acide formique,collo-bueglatt PubChem CID: 284 ChEBI: CHEBI:30751 IUPAC Name: formic acid SMILES: C(=O)O
Formic Acid, 88%, BAKER ANALYZED™ A.C.S. Reagent, J.T. Baker™
CAS: 64-18-6 Molecular Formula: CH2O2 Molecular Weight (g/mol): 46.025 InChI Key: BDAGIHXWWSANSR-UHFFFAOYSA-N Synonym: methanoic acid,formylic acid,aminic acid,bilorin,hydrogen carboxylic acid,formisoton,myrmicyl,formira,acide formique,collo-bueglatt PubChem CID: 284 ChEBI: CHEBI:30751 IUPAC Name: formic acid SMILES: C(=O)O
Sigma Aldrich Fine Chemicals Biosciences SIGMA ALDRICH FINE CHEMICALS BIOSCIENCES
NC3924754 SIGMA FORMIC ACID 98 - 100