Formic Acid
Formic acid (HCOOH) is naturally-occurring, flammable, corrosive, organic, and the simplest carboxylic acid. Used as a hydride ion source in synthetic organic chemistry, a mobile phase component in HPLC, a preservative/antibacterial agent in agriculture, etc.
Formic or methanoic acid (CAS: 64-18-6; PubChem ID: 284) is a colorless organic acid with the formula HCOOH. At ambient temperatures, it has a strong, penetrating odor, like acetic acid. Used in chemical synthesis as an intermediate, this simple carboxylic acid is miscible in water and most organic solvents and is somewhat hydrocarbon-soluble.
Formic acid occurs naturally in the venom of some ants and bees. Formate, the conjugate base of formic acid, also occurs naturally in bodily fluids following methanol poisoning.
Formic acid is a source of hydride ion in synthetic organic chemistry, as in the Eschweiler-Clarke and Leuckart-Wallach reactions. It is also a useful component of the mobile phase in reversed-phase high-performance liquid chromatography (RP-HPLC) for peptides, proteins, and intact viruses.
Although formic acid is easily metabolized and eliminated, it can have toxic effects. Methanol metabolism produces formic acid and formaldehyde, which are responsible for the optic nerve damage that results from methanol poisoning. Chronic exposure in humans may cause kidney damage and skin allergies in some people.
In diluted forms, formic acid and formate esters are used as artificial flavorings and perfume additives. In higher concentrations, formic acid is flammable, and skin and eye contact with concentrated liquid or vapors is dangerous.
In agriculture, formic acid is used as a preservative and antibacterial agent and by beekeepers to kill mites. It is useful in leather tanning, textile dyeing and finishing, and in rubber production. Formic acid replaces mineral acids in limescale removers and other cleaning products.
eMolecules 64-18-6 | Formic Acid, ACS Grade | Oakwood Chemical | MFCD00003297 | 46.025 | CH2O2 | 88.000 | OC=O | 1kg | 736631842
Formic Acid, ACS Grade | Oakwood Chemical | 64-18-6 | MFCD00003297 | 46.025 | CH2O2 | 88.000 | OC=O | 1kg | 736631842
Medchemexpress LLC SJ1008030 formic | 2863634-96-0 | 97.7% | 919.96 | 50 MG
SJ1008030 formic is a JAK2 PROTAC that selectively degrades JAK2, making it suitable for leukemia research. It inhibits MHH-CALL-4 cell growth with an IC50 of 5.4 nM.
- Selectively degrades JAK2
- Inhibits MHH-CALL-4 cell growth
- Useful for leukemia research
- Degrades JAKs, GSPT1, and IKZF1 in a dose-dependent manner
- Inhibits JAK-STAT signaling pathway
eMolecules 64-18-6 | Formic Acid, ACS Grade | Oakwood Chemicals | MFCD00003297 | 46.025 | CH2O2 | 88.000 | OC=O | 4kg | 480143865
Formic Acid, ACS Grade | Oakwood Chemicals | 64-18-6 | MFCD00003297 | 46.025 | CH2O2 | 88.000 | OC=O | 4kg | 480143865
Medchemexpress LLC MRTX-EX185 formic | 2988148-70-3 | 97.23% | C34H35FN6O4 | 1 ML
MRTX-EX185 formic is a potent KRAS (G12D) inhibitor with an IC50 of 90 nM. It binds to both GDP-loaded and active GNP states of KRAS and KRAS (G12D). This compound exhibits broad-spectrum binding properties and can be utilized for studying various RAS-driven tumors, such as pancreatic cancer.
- Suppresses cell proliferation in KRAS (G12D)-driven SW-1990 pancreatic cancer cells with an IC50 of 70 nM.
- Non-toxic to non-KRAS-dependent cell lines (HEK293 cells).
- Significantly inhibits ERK phosphorylation (p-ERK) in KRAS(G12C)-driven cell lineages.
Medchemexpress LLC OAB-14 | 2140911-49-3 | 99.2% | 518.73 | 1 ML
OAB-14 is a derivative of Bexarotene that improves Alzheimer's disease-related pathologies and cognitive impairments. It works by increasing β-amyloid clearance and ameliorating the dysfunction of the endosomal-autophagic-lysosomal pathway in APP/PS1 transgenic mice. OAB-14 has no significant effect on body weight or liver toxicity after acute and chronic treatment.
- Improves Alzheimer's disease-related pathologies and cognitive impairments
- Increases β-amyloid clearance
- Ameliorates dysfunction of the endosomal-autophagic-lysosomal pathway
- Promotes microglia phagocytosis
- Attenuates downstream pathological events of Aβ accumulation
- Restores autophagy flux via the AMPK/mTOR pathway
- Enhances lysosomal activity and reduces Aβ accumulation in lysosomes
TARGETMOL CHEMICALS INC QUILSECONAZOLE FORMIC AC 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Quilseconazole Formic acid is a selective inhibitor of fungal Cyp51 with potent activities against Cryptococcus neoformans and Cryptococcus gattii.
Medchemexpress LLC Dl-01 formic | 2964513-44-6 | 98.5% | 1144.30 | C56H73N9O15S | 5 MG
DL-01 formic is a drug-linker conjugate used in the synthesis of antibody-drug conjugates (ADCs) and related research applications. It is supplied as a high-purity solid for laboratory research use only and should be handled and stored according to the product datasheet and safety documentation.
- Drug-linker conjugate for ADC synthesis
- High purity (approximately 98.5%) solid, white to light yellow
- Molecular formula C56H73N9O15S and molecular weight 1,144.30
- CAS number 2964513-44-6
- Store at -80°C, protect from light, store under nitrogen
Formic Acid, 88%, BAKER ANALYZED™ A.C.S. Reagent, J.T. Baker™
CAS: 64-18-6 Molecular Formula: CH2O2 Molecular Weight (g/mol): 46.025 InChI Key: BDAGIHXWWSANSR-UHFFFAOYSA-N Synonym: methanoic acid,formylic acid,aminic acid,bilorin,hydrogen carboxylic acid,formisoton,myrmicyl,formira,acide formique,collo-bueglatt PubChem CID: 284 ChEBI: CHEBI:30751 IUPAC Name: formic acid SMILES: C(=O)O
Formic Acid (Aldehyde-Free/Sequencing), Fisher BioReagents™
CAS: 64-18-6 Molecular Formula: CH2O2 Molecular Weight (g/mol): 46.025 InChI Key: BDAGIHXWWSANSR-UHFFFAOYSA-N Synonym: methanoic acid,formylic acid,aminic acid,bilorin,hydrogen carboxylic acid,formisoton,myrmicyl,formira,acide formique,collo-bueglatt PubChem CID: 284 ChEBI: CHEBI:30751 IUPAC Name: formic acid SMILES: C(=O)O
Sigma Aldrich Fine Chemicals Biosciences SIGMA ALDRICH FINE CHEMICALS BIOSCIENCES
NC3924754 SIGMA FORMIC ACID 98 - 100
